@Mako88 wrote: if you create an editable region in a template with content in it, every time you leave the page on the admin panel it will ask you to save the data until you do.
You know, I'm not positive because I wasn't thinking about it then, but I bet this is what was happening in my case. I was working on new templates and kind of modifying them as I went along. I haven't had this issue come up again since then.
Thanks, @Mako88. I think you found the problem.